|
Product Applications
The molecular diagnostics market consists of
fairly mature products for infectious diseases
and blood transfusion products as well as newer
products for gene-based disorders, blood and
organ transplantation, inherited diseases, and
cancer. The majority of testing within the
molecular diagnostics market consists of nucleic
acid-based tests for detecting pathogenic
bacteria and viruses. In some cases, these tests
can also detect antibiotic resistance. Molecular
tests have also made the blood transfusion
industry much safer due to their ability to
detect lower concentrations of pathogens and
viruses in donated blood. Test applications in
this area include tests for sexually transmitted
diseases, hepatitis (HAV, HBV, HCV), human
immuno-deficiency virus (HIV), and West Nile
virus.
Likely Molecular
Diagnostic Applications
|
Application |
Description |
|
HLA Testing
|
Class I HLA
Genotyping
Class II HLA Genotyping
HLA Class I Antibody Identification
HLA Class II Antibody Identification
KIR Genotyping
Disease association studies |
|
Infectious Diseases |
Influenza A & B,
RSV,
Parainfluenza 1-3 (non-differentiated), Adenovirus/hMPV,
Corona virus,
Rhino virus,
Bocavirus,
B. pertussis,
B. parapertussis,
C. pneumo,
M. pneumo,
L. pneumo,
Staph aureus/MRSA,
E.faecium & E. faecalis,
Van A/Van B,
Entero virus,
HSV,
VZV,
CMV,
EBV,
HHV6 |
|
Antibiotic Resistant Bacterial Infections |
Development of a diagnostic panel for detection
of vancomycin-resistant enterococci (VRE)
and methicillin-resistant Staphylococci (MRSA). |
|
Cancer |
Breast,
Prostate,
Colorectal,
Lung,
Liver,
Skin,
Blood Markers |
|
Autoimmune |
ANA Screen - ds DNA,
Chromatin,
Ribosomal
Protein,
SS-A (52 & 60),
SS-B,
Sm, Sm/RNP,
RNP
(A & 68),
Scl-70,
Jo-1,
Centromere B,
Vasculitis,
Anti-MPO,
Anti-PR3,
Anti-GBM,
Gastrointestinal IgA,
Gastrointestinal IgG,
Anti-Phospholipid
Syndrome IgG,
Anti-Phospholipid Syndrome IgA,
Rheumatoid
Arthritis |
|
Genetic Screening |
Genotyping
Mitochondrial DNA Screening, Y-SNP
Identification
Transcription Factors
-
AP-1, AP-2, AR, CRE-ATF1, CREB, E2F1-5,
E2F6
-
EGR, GATA, HIF-1, HNF1, HNF4, ISRE, Myc-Max
-
NF-1, NFAT, NFkB, NFkB Gene Family, p53
-
PPAR, SMAD 2/3, SP1, SRE, YY1
|
|
