Digital Multiplexing
One Multiplex Platform - ported from high plex Biomarker Discovery directly to lower plex IVD Assay

Applied BioCode, Inc. (ABC) develops cutting edge, patented and validated barcoded magnetic beads technology for multiplex bioassay.  The Barcoded Magnetic Beads (BMB), utilizing a digital technology instead of conventional analog methodology, offers unmatched decoding accuracy, excellent fluorescence detection precision and an unlimited number of barcodes for multiplex tests.  Depending on the number of digits (N) on a single microbead, the number of unique identification codes, 2^N, can be easily extended from 128 (=2⁷) to 4,096 (=2¹²). When BMB technology marries biotechnology, it becomes a very dynamic and powerful platform for a wide variety of biological applications, such as routine clinical diagnostics, gene mutation analysis, infectious diseases, biomarkers validation, drug resistance genotyping, and pharmaceutical drug discovery. 

Because of BMB simplicity, reliability, scalability, and exceptionally low cost, this technology can change the format of future in-vitro and molecular diagnostics.

Advantages of our technology:

• Open-ended Barcode Number - Digital multiplexing offers unlimited barcodes by simply adding more digits.

• High Decoding Accuracy - High contrast optical barcodes enable accurate decoding; no ambiguous barcode classification.

• No Bead Photon-Bleaching and No Fluorescence Interference – Permanent barcodes on BMB, ambient light stable, and without fluorescence interference from impregnated dyes.

• Fewer Lot-to-Lot Variations – Semiconductor manufacturing process is highly reproducible.  All beads are created equal. Only the barcode varies.

• Ease of Operation – BioCode Analyzer is similar to ELISA reader, all processes can be performed in a 96-well microplate without bead loss.  BMB’s paramagnetic properties make them well suited for automation.

• Robust & Easy to Maintain – No complicated lasers, no flow cytometer, and no waste bottles.

ABC maintains an extensive collaborative network with universities, government laboratories, and industrial partners. We are able to leverage our powerful tools and collaborative network to maximize the benefit to our customers.